This article is a truly thought-provoking contribution to na extensive yet not always critical literature on the ayahuasca diaspora. Against the ever-encroaching desire of Western globalism and its invincible romantic modernist primitivism to absorb difference into an overall “oneness,” where everything human meets and melts, the authors prefer to look at the undeniable contrast that opposes indigenous Amazonian and Euro-Australian ways of experiencing the “mental imagery” induced by the ingestion of ayahuasca, famous for its vivid visionary potential. After having convincingly argued in favor of the profound difference that separates both, the authors conclude with a pessimistic note: “A European Enlightenment political philosophy embodied in perennial mystical visions and plant-spirit healing has eroded the foundations of indigenous morality and its social means of affect.”